Medications that can provoke seizures
| DEFINITE INCREASE IN RISK (>0.1%) | ||
| bupropion | Wellbutrin ® | >300 mg/day |
| clozapine | Clozaril ®, Fazaclo ® | |
| flurazepam | Dalmane ® | In withdrawal |
| theophylline | Uniphyl ® | |
| POSSIBLE MODERATE INCREASE IN RISK (>0.01% but <0.1%) | ||
| acyclovir | Zovirax ® | |
| 4-aminopyridine | Fampridine ® | |
| alprazolam | Xanax ® | In withdrawal |
| amitriptyline | Elavil ® | |
| amoxapine | Moxadil ® | |
| aripiprazole | Abilify ® | |
| atomexietine | Strattera ® | |
| buspirone | BuSpar ® | |
| cefixime | Suprax ® | |
| citalopram | Celexa ® | |
| clomipramine | Anafranil ® | |
| cyclobenzaprine | Amrix ®, Flexeril ® | |
| duloxetine | Cymbalta ® | |
| epoetin | Epogen ® | |
| fluoxetine | Prozac ® | |
| inteferon beta-1a | Avonex ® | |
| inteferon beta-1b | Rebif ®, Betaseron ® | |
| memantine | Namenda ® | |
| meropenem | Merrem ® | |
| mitoxantrone | Novantrone ® | |
| ofloxacin | Floxin ® | |
| olanzapine | Zyprexa ® | |
| paroxetine | Paxil ® | |
| protriptyline | Vivactil ® | |
| quietapine | Seroquel ® | |
| risperidone | Risperdal ® | |
| sertraline | Zoloft ® | |
| sibutramine |
Meridia ® |
|
| torsemide | Demadex ® | |
| trihexyphenidyl | Artane ® | |
| venlafaxine | Effexor ® | |
| ziprasidone | Geodon ® | |
| POSSIBLE SLIGHT INCREASE IN RISK ( <0.01% but >0.001%) | ||
| clomiphene | Clomid ® | |
| dantrolene | Dantrium ® | |
| desipramine | Norpramin ® | |
| doxepin | Sinequan ® | In withdrawal |
| escitalopram | Lexapro ® | |
| etoposide | Vepesid ® | |
| glatiramer | Copaxone ® | |
| haloperidol | Haldol ® | |
| mirazapine | Remeron ® | |
| nortriptyline | Pamelor ® | |
| oxytocin | Pitocin ® | |
| Percodan ® | Percocet ® | |
| thiothixene | Navane ® | |
| tizanidine | Zanaflex ® | |
| trifluperazine | Stelazine ® | |
| POSSIBLE VERY SLIGHT INCREASE IN RISK (<0.001%) | ||
| baclofen | Lioresal ® | In withdrawal |
| busulfan | Myleran ® | |
| chlorambucil | Leukeran ® | |
| chlorpromazin | Thorazine ® | |
| diphenhydramine | Benadryl ® | In withdrawal |
| hydroxyzine | Atarax ®, Vistaril ® | In withdrawal |
| lorazepam | Ativan ® | In withdrawal |
| molindone | Moban ® | |
| ondansetron | Zofran ® | |
| phenylpropanolamine | Dexatrim ® | |
| terbutaline | Terbutaline ® | |
| REPORTED ASSOCIATION WITH SEIZURE, BUT UNKNOWN INCREASE IN RISK | ||
| Alcohol | In withdrawal | |
| almotriptan | Axert ® | |
| aminophylline | Truphylline ® | |
| Amphetamines | Adderal ® | |
| amphotericin B | Amphotec ® | |
| atorvastatin | Lipitor ® | |
| azathioprine | Imuran ® | |
| benztropine | Cogentin ® | |
| bromocriptine | Parlodel ® | |
| bupivicaine | Marcaine ® | |
| cabergoline | Dostinex ® | |
| caffeine | Cafcit ® | |
| captopril | Capoten ® | |
| carisoprodol | Soma ® | In withdrawal |
| carvedilol | Coreg ® | |
| cefepime | Maxipime ® | |
| cefotetan | Cefotan ® | |
| ceftazidime | Fortaz, Tazidime ® | |
| cefuroxime | Zinacef ® | |
| cephalexin | Keflex ® | |
| chloroquine | Aralen ® | |
| ciprofloxacin | Cipro ® | |
| cisplatinum | Cisplatin ® | |
| clonazepam | Klonopin ® | In withdrawal |
| clorazepate | Tranxene ® | In withdrawal |
| Cocaine | ||
| cyclophosphamide | Cytoxan ® | |
| cyclosporin | Sandimmune ®, Gengraf ® | |
| dexmethylphenidate | Focalin ® | |
| dexoamphetamine | Dexedrine ® | |
| dextroamphetamine | Dexedrine ® | |
| diazepam | Valium ® | In withdrawal |
| dicyclomine | Bentyl ® | |
| donepezil | Aricept ® | |
| doripenem | Doribax ® | |
| doxorubicin | Adriamycin ® | |
| dronabinol | Marinol ® | |
| efavirenz | Sustiva ® | |
| enfluraneketamine | Enflurane ® | |
| entacapone | Comtan ® | |
| estazolam | ProSom ® | In withdrawal |
| estrogen | Premarin ® | |
| eszopiclone | Lunesta ® | In withdrawal |
| fentanyl | Duragesic ® | |
| fluphenazine | Prolixin ® | |
| fluvastatin | Lescol XL ® | |
| ganciclovir | Cytovene ® | |
| gemifloxacin | Factive ® | |
| Ginko biloba | ||
| imipenim/Cilastin | Primaxin ® | |
| indomethacin | Indocin ® | |
| Isoniazid | Nydrazid ® | |
| ivermectin | Stromectol ® | |
| ketorolac | Toradol ® | |
| levofloxacin | Levaquin ® | |
| lidocaine | Xylocaine ® | |
| lindane | Agrocide ® | |
| linezolid | Zyvox ® | |
| lithium | Lithobid ® | |
| lomefloxacin | Maxaquin ® | |
| loxapine | Loxitane ® | |
| mefenamic acid | Ponstel ® | |
| mefloquin | Larium ® | |
| meperidine | Demerol ® | |
| mephobarbital | Mebaral ® | In withdrawal |
| methocarbamol | Robaxin ® | |
| methotrexate | Trexall ® | |
| methylphenidate | Concerta ®, Ritalin ® | |
| metronidazole | Flagyl ® | |
| modafinil | Provigil ® | |
| montelukast | Singulair ® | |
| moxifloxacin | Avelox ® | |
| mycophenolate | CellCept ® | |
| nalidixic acid | Negram ® | |
| oxybutynin | Ditropan ® | |
| oxycodone | Oxycontin ® | |
| oxymorphone | Opana ® | |
| pentazocine | Talwin ® | |
| phenobarbital | Luminal ® | In withdrawal |
| pimozide | Orap ® | |
| pramipexole | Mirapex ® | |
| prednisone | Deltason ® | |
| primidone | Mysoline ® | In withdrawal |
| procaine | Novocain ® | |
| promethazine | Phenergan ® | |
| propoxyphene | Darvon ® | |
| rameltron | Rozerem ® | In withdrawal |
| rasagiline | Azilect ® | |
| rivastigmine | Exelon ® | |
| ropinerole | Requip ® | |
| selegiline | Eldeprel ® | |
| sildenafil | Viagra ® | |
| sodium oxybate | Xyrem ® | |
| sumatriptan | Imitrex ® | |
| tacrine | Cognex ® | |
| tacrolimus | Prograf ® | |
| tadalafil | Cialis ® | |
| temazepam | Restoril ® | In withdrawal |
| temozolomide | Temodar ® | |
| thalidomide | Thalomid ® | |
| thioridazine | Mellaril ® | |
| ticlopidine | Ticlid ® | |
| tinidazole | Tindamax ® | |
| tolcapone | Tasmar ® | |
| tolterodine | Detrol-LA ® | |
| tranylcypromine | Parnate ® | |
| triazolam | Halcion ® | In withdrawal |
| valacyclovir | Valtrex ® | |
| valsartan | Diovan ® | |
| vardenafil | Levitra ® | |
| vincristine | Oncovin ® | |
| zaleplon | Sonata ® | In withdrawal |
| zanamivir | Relenza ® | |
| ziconotide | Prialt ® | |
| zidovudine | Retrovir capsules ® | |
| zolpidem | Ambien ® | In withdrawal |