Causes
• Structural abnormalities of the brain:
- Lissencephaly (smooth brain)
- Cortical Dysplasia (cortex malformation)
- Porencephaly (abnormal fluid space)
• Genetic causes
- Chromosomal causes: Down Syndrome
- Genetic: Tuberous Sclerosis
• Metabolic Causes
- Pyrodoxine (Vitamin B6) Deficiency
* This can be a reversible cause of IS by replacing the missing vitamin
• Infectious Causes
- Infection in the womb or after birth affecting the brain fluid (meningitis) or brain tissue (encephalitis) by a bacteria or virus
• Birth Injury
- Lack of blood and oxygen to the brain